¹⁸Fluorine-sodium fluoride positron emission tomography to evaluate arterial calcification in patients with chronic kidney disease: a pilot study.

ABSTRACT: ¹⁸Fluorine-Sodium Fluoride Positron Emission Tomography (¹⁸F-NaF PET) allows for the detection of arterial micro-calcification, but its data on people with chronic kidney disease (CKD) is limited. This pilot study aimed to determine the optimal time to perform ¹⁸F-NaF PET static scan and to characterize arterial macro- and micro-calcification in CKD. In 7 patients with CKD stages 3b-4 and 3 non-CKD individuals, following the injection of ¹⁸F-NaF, an electrocardiogram-gated chest CT, a 30-min dynamic PET, and three 10-min static PET were acquired. Radiopharmaceutical uptake was quantified for regions including the lumbar spine and 4 aortic segments. Arterial macro-calcification was quantified using Agatston scoring and micro-calcification using ti

SUBMITTER: Shokrekhuda AM 

PROVIDER: S-EPMC12628283 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature