Estrogen-Functionalized Ru(II) Polypyridyl Complexes Self-Assemble into Aggregates and Exhibit Selective Phototoxicity against Breast Cancer Cells.

ABSTRACT: Photodynamic therapy (PDT) constitutes a promising cancer treatment modality in which an administered photosensitizer is excited with visible light to induce the localized generation of cytotoxic reactive oxygen species (ROS) at the tumor site, thus minimizing damage to healthy tissues and avoiding the use of ionizing radiation. However, most photosensitizers lack inherent selectivity for cancer cells, leading to undesirable accumulation in healthy tissues. The readily formed triplet excited states of Ru(II) polypyridyl complexes, coupled with their kinetic inertness, make them suitable candidates as photosensitizers for PDT. Herein, we report the synthesis of a series of estrogen-functionalized Ru(II) complexes using click chemistry and investigate their photophysical properties and biolo

SUBMITTER: Tsoni SA 

PROVIDER: S-EPMC12628291 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature