Novel bakuchiol derivatives inhibit the migration and invasion of non-small cell lung cancer by suppressing epithelial-to-mesenchymal transition.

ABSTRACT: Recently, bakuchiol and its derivatives have been widely investigated owing to their anticancer activity. However, there are few studies on the inhibition of epithelial-mesenchymal transition (EMT) by bakuchiol and its derivatives. Besides, thiosemicarbazones (TSCs) have also been demonstrated to exhibit potential EMT-inhibitory effects. Hence, the cytotoxic activity of novel bakuchiol derivatives containing thiosemicarbazone moieties was evaluated against two non-small lung cancer cell lines. Among them, compound 2f demonstrated the highest activity, with IC₅₀ values of 2.23 and 5.55 µM against PC9 and H1975 cells, respectively. Compound 2f effectively suppresses tumor cell proliferation by inducing cell cycle arrest and promoting apoptosis. Additionally, various evidence after

SUBMITTER: Xu MF 

PROVIDER: S-EPMC12628304 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature