Contributing effects of sarcopenia on cancer occurrence: novel evidence based on NHANES 1999-2020 and two-sample mendelian randomization study.

ABSTRACT:

Background

Sarcopenia is associated with worse prognosis in patients with cancer, and patients with cancer usually have poor muscle condition. However, it is still not clear whether sarcopenia contributes to cancer occurrence.

Methods

This study utilized data from the National Health and Nutrition Examination Survey (NHANES) 1999-2020 to assess the relationship between sarcopenia and cancer. Key sarcopenia indicators, including lean mass measurements and sarcopenia diagnosed by European Working Group on Sarcopenia in Older People (EWGSOP) or Foundation for the National Institutes of Health (FNIH) criteria, were analyzed using quantile logistic regression models. A two-sample Mendelian Randomization (MR) approach was employed to explore the causal link between sarcopenia and

SUBMITTER: Xu Z 

PROVIDER: S-EPMC12628308 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature