Long-term effects of premenopausal risk-reducing salpingo-oophorectomy on bone mineral density.

ABSTRACT: Women at high familial risk for ovarian cancer are recommended to undergo risk-reducing salpingo-oophorectomy (RRSO), leading to surgical menopause and short-term bone loss. However, long-term studies and osteoporosis screening recommendations are lacking. Eighteen years after premenopausal RRSO, women had lower bone mineral density compared with women who underwent a postmenopausal RRSO.

Purpose

To prevent ovarian cancer, BRCA1/2 germline pathogenic variant carriers are recommended to undergo premenopausal risk-reducing salpingo-oophorectomy (RRSO). Premenopausal RRSO leads to immediate menopause, which has been associated with an acute phase of rapid bone loss. However, data on long-term bone mineral density (BMD) is scarce and inconclusive. We aimed to investigate long-term BMD a

SUBMITTER: Beekman MJ 

PROVIDER: S-EPMC12628374 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature