PDCD1 as a targetable immune checkpoint hub: therapeutic insights for ibrutinib-resistant CLL management.

ABSTRACT: Chronic lymphocytic leukemia (CLL) is a type of cancer that affects the blood and bone marrow, specifically involving the overproduction of abnormal lymphocytes. Using two independent datasets (GSE249956 and GSE98206), differentially expressed genes (DEGs) were identified between ibrutinib-resistant and sensitive CLL samples. Protein-protein interaction (PPI) network analysis revealed key hub genes related to resistance. Three common hub genes were shared across datasets: PDCD1, CD1C, and ITGB2. PDCD1, encoding the immune checkpoint protein PD-1, was selected for deeper investigation due to its important role in immune regulation and relevance in drug resistance. Post-transcriptional regulation of PDCD1 was explored by the construction of competing endogenous RNA (ceRNA) networks linking l

SUBMITTER: Kalaki NS 

PROVIDER: S-EPMC12628378 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature