Evaluating the Impact of Urolithin A Supplementation on Running Performance, Recovery, and Mitochondrial Biomarkers in Highly Trained Male Distance Runners.

ABSTRACT:

Background

Urolithin A (UA) is a metabolite produced by gut bacteria following the consumption of ellagitannin-rich foods. Clinical trials in middle-aged and older adults demonstrated that supplementation with UA improves muscle strength, endurance, and biomarkers of mitochondrial health, suggesting that UA may be an effective ergogenic aid in other populations.

Methods

In this double-blind, parallel group, placebo-controlled clinical trial (NCT04783207), competitive male distance runners (n = 42, 27.2 ± 1.0 years, V˙O2max 66.4 ± 0.6 mL·kg^-1·min^-1, mean ± SEM) were randomized to consume either 1000 mg·day^-1 UA (n = 22) or placebo (PL; n = 20) for 4 weeks during an altitude training camp (~ 1700-2200 m). Physiological outcomes including body c

SUBMITTER: Whitfield J 

PROVIDER: S-EPMC12628386 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature