Effectiveness of treatment initiation for secondary fracture prevention in the older population: Japanese Bone-fracture Osteoporosis in Late-stage population Database study (J-BOLD) - emulation of a randomized target trial.

ABSTRACT: Initiating osteoporosis medication within 3 months after fracture reduces secondary fractures, particularly hip fractures, in individuals aged ≥ 75 years. This finding highlights the importance of early and sustained treatment in older populations.

Purpose

To evaluate the efficacy of initiating osteoporosis medication within 3 months after a fracture and continuing it for at least 6 months in preventing secondary fractures among individuals aged ≥ 75 years.

Methods

This study used a targeted trial design, emulating a randomized controlled trial with Japanese administrative claims data from 2014-2022. Among 203,534 individuals with recent osteoporotic fractures, 40,063 initiated osteoporosis medication within 3 months (exposed), while 163,471 did not (controls). High-dimension

SUBMITTER: Tsukamoto M 

PROVIDER: S-EPMC12628409 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature