CD2AP is a disulfidptosis modulator and prognostic biomarker in hepatocellular carcinoma.

ABSTRACT: CD2-associated protein (CD2AP) is an adapter protein that stabilizes the actin cytoskeleton and is closely linked to disulfidptosis. However, its functional role in hepatocellular carcinoma (HCC) progression and disulfidptosis remains undefined. Herein, pan-cancer multiomics analyses were performed on 33 malignancies from The Cancer Genome Atlas (TCGA) and Genotype-Tissue Expression (GTEx) cohorts to evaluate CD2AP expression patterns, prognostic significance, and interactions with the tumor immune microenvironment. Clinical validation was performed using 70 HCC specimens, with qRT-PCR analysis and survival assessments. CD2AP expression was significantly elevated in tumor tissues across multiple cancer types and correlated with poor survival outcomes. In tumor tissues, high CD2AP expressio

SUBMITTER: Tan Y 

PROVIDER: S-EPMC12628418 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature