Exploring the natural history of bone mineral density in Duchenne muscular dystrophy: a systematic literature review.

ABSTRACT:

Purpose

In Duchenne muscular dystrophy (DMD) osteoporosis and fragility fractures present significant comorbidities, resulting from progressive myopathy reduced weight-bearing and osteotoxic effects of prolonged glucocorticoid (GC) use. This systematic literature review (SLR) assessed the natural course of bone mineral density (BMD) in individuals with DMD and the factors associated with its natural progression.

Methods

A systematic literature review was conducted to evaluate BMD in individuals with DMD. Searches were performed in PubMed® and Embase® for peer-reviewed articles published between 2000 and 2023, focusing on DMD patients aged 5-15 years receiving GC treatment. Statistical analyses employed an initial correlation analyses followed by generalized linear mixed mode

SUBMITTER: De Ford C 

PROVIDER: S-EPMC12628439 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature