Serum tRF-18-HR05X6D2 may serve as a promising potential diagnostic biomarker for gastric cancer.

ABSTRACT: Gastric cancer (GC) presents with insidious early symptoms that lack distinctiveness. Coupled with insufficient screening awareness and limited diagnostic methods, these symptoms are difficult to distinguish from manifestations of benign conditions including gastritis and gastric ulcers, leading patients to seek medical attention only after advanced-stage symptoms develop. Traditional serum markers exhibit low positivity and specificity in early-stage GC; therefore, actively identifying novel molecules for combined diagnosis in conjunction with traditional biomarkers proves essential for the early diagnosis of GC. tRNA-derived small RNAs (tsRNAs), a novel category of non-coding RNAs (ncRNAs), exhibit promise as liquid biopsy indicators and can engage in the pathological processes of cancer

SUBMITTER: Li X 

PROVIDER: S-EPMC12628448 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature