Association of preoperative Circulating biomarkers with echocardiographic measures of right ventricular strain five years after tetralogy of fallot repair.

ABSTRACT:

Purpose

We analyzed right ventricular (RV) function using echocardiography after tetralogy of Fallot (TOF) repair to investigate the association between preoperative circulating biomarkers and RV strain five years after repair. We hypothesized that biomarkers of myocardial fibrosis and stretch would be correlated with worse mid-term RV function measured by strain.

Methods

We included children repaired at our institution from 2016 to 2019. Biomarkers measured preoperatively included galectin-3, Procollagen-type-I carboxy-terminal-propeptide (PICP), Procollagen-type-III-amino-terminal-propeptide (PIIINP), matrix-metalloproteinase-1 (MMP1), matrix-metalloproteinase-9 (MMP9), soluble suppression of tumorigenicity-2 (sST2), and N-terminal-pro-B-type-natriuretic-peptide (NT pro-BN

SUBMITTER: Galan JA 

PROVIDER: S-EPMC12628454 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature