Transcriptomic landscape of generalized pustular psoriasis before and after acitretin/glucocorticoids treatment.

ABSTRACT: Generalized pustular psoriasis (GPP) is a rare and severe subtype of psoriasis, characterized by sterile pustules on the skin surface. Acitretin is currently one of the first-line treatments for GPP, while glucocorticoids are commonly used in patients with hyperpyrexia. However, the pathogenesis of GPP and the mechanisms of these drugs need to be further clarified. The clinical characteristics of GPP before and after treatment were collected and compared using student t tests or paired Wilcoxon tests. We analyzed the transcriptomic features of GPP using publicly available sequencing data. Subsequently, RNA sequencing of peripheral blood mononuclear cells (PBMCs) from 29 GPP patients before and after treatment was conducted. The patients were divided into one group treated with acitretin al

SUBMITTER: Shen S 

PROVIDER: S-EPMC12628471 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature