PSMA-1-DOTA Potentially for Effective Targeted Radioligand Therapy of Prostate Cancer.

ABSTRACT:

Purpose

While PSMA-targeted radioligand therapy (RLT) has shown remarkable efficacy for treating end-stage prostate cancer, the α-emitting RLT often results in severe salivary gland toxicity, limiting its use. Various strategies to mitigate this side effect have been attempted with limited success. Accordingly, this study introduced a new PSMA-targeting ligand with more favorable binding characteristics than the existing ligands.

Procedures

The binding affinity of PSMA-1-DOTA to PSMA was compared with that of PSMA-11 and PSMA I&T. Comparison of uptake in the salivary glands, kidneys and PC3pip tumor cells in the xenograft mouse models between [⁶⁸ Ga]Ga-PSMA-1-DOTA, [⁶⁸ Ga]Ga-PSMA-11 and [⁶⁸ Ga]Ga-PSMA I&T was conducted with microPET/CT within

SUBMITTER: Wang X 

PROVIDER: S-EPMC12628472 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature