SOAT1 in ovarian cancer cells regulates immune response mediated by CD8⁺ T cells.

ABSTRACT:

Background

Sterol-O acyltransferase 1 (SOAT1) functions by converting cholesterol and acyl-CoA into cholesterol ester and CoA-SH. SOAT1 inhibition suppresses tumor growth. A recent study has shown that inhibiting cholesterol esterification in T cells using genetic manipulation or drug treatment of SOAT1 boosted the cytotoxicity of CD8⁺ T cells. To better understand the role of SOAT1 in the tumor immune microenvironment of ovarian cancer (OC) and to optimize combined immunotherapy strategies, we examined the effect of SOAT1 manipulation and drug inhibition in OC cells on CD8⁺ T cell-mediated immune response in vitro.

Results

Correlation analysis results obtained using GEPIA2 showed that SOAT1 expression was positively correlated with cytotoxic CD8^+<

SUBMITTER: He J 

PROVIDER: S-EPMC12628612 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature