Comparable renal effects of histidine-tryptophan-ketoglutarate and DelNido cardioplegia in a porcine model of cardiac arrest.

ABSTRACT: Acute kidney injury (AKI) is a serious complication following on-pump cardiac surgery. Choosing the cardioplegic solution with the most appropriate myocardial protection and lowest grade of AKI could improve patient outcome. We compared the crystalloid histidine-tryptophan-ketoglutarate (HTK) solution and a Jonosteril^®-based DelNido blood cardioplegic solution regarding AKI in a porcine model. Therefore, German landrace pigs (50-60kg) underwent median sternotomy, cardiopulmonary bypass at 34 °C and 90 min of cardiac arrest. Animals were randomized to single-shot cardioplegia of HTK (n = 9) or DelNido (n = 9) cardioplegic solution followed by 120 min of reperfusion. This study demonstrated that DelNido cardioplegia induced less hemoglobin (p < 0.01) and elect

SUBMITTER: Dieterlen MT 

PROVIDER: S-EPMC12628664 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature