Exercise-induced modulation of IGF-1 in healthy, obese, and cancer populations: a systematic review and meta-analysis.

ABSTRACT:

Background

This systematic review and meta-analysis evaluated the effects of chronic exercise on circulating insulin-like growth factor 1 (IGF-1) across different populations, including, healthy adults, individuals with obesity, and cancer patients or survivors. To minimize confounding, we excluded trials combining exercise with medications, hormone therapy, or structured dietary interventions.

Materials and methods

PubMed and Embase were searched through July 2024 for randomized controlled trials (RCTs) in adults (≥18 years) with exercise interventions lasting ≥8 weeks, a non-exercise control group, and reported changes in serum IGF-1. Twenty-one RCTs with 1376 participants met the inclusion criteria. Pooled weighted mean differences (WMD) with 95% confidence intervals (CI)

SUBMITTER: Kwon YR 

PROVIDER: S-EPMC12628670 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature