Growth and acetate metabolism of <i>Staphylococcus aureus</i> in defined medium.

ABSTRACT: Staphylococcus aureus is a major human pathogen that has emerged as a model pathogen to study growth and metabolism. Many investigators have designed defined media (complete defined medium; CDM) to investigate staphylococcal genetic and metabolic processes. Previous S. aureus growth studies have found that acetate is not consumed following glucose catabolism in certain CDM recipes, nor are arginine and proline consumed, suggesting a defect in post-exponential growth. The current studies found that acetate catabolism is dependent upon the coordinated action of acetyl-CoA synthetase (Acs), the AcuA acetylase, and AcuC deacetylase. Furthermore, it was determined that acetate catabolism in S. aureus in CDM is linked to a critical ratio between the concentration of amino ac

SUBMITTER: Razvi F 

PROVIDER: S-EPMC12628684 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature