Impact of the lipid-inflammation axis on endometriosis risk: a multicenter case-control study using mediation analysis.

ABSTRACT:

Background

Endometriosis (EM) is often accompanied by dyslipidemia, but the causal relationship between dyslipidemia and inflammation remains unclear. This study aimed to explore the association between the lipid-inflammation axis and EM risk and to quantify the mediating role of the systemic immune-inflammation index (SII).

Methods

A total of 357 EM cases and 3134 controls were included. Blood lipids and SII were assessed using logistic regression, generalized additive models (GAM), and bootstrap mediation analysis. Least absolute shrinkage and selection operator (LASSO) modeling was applied, and the model was further evaluated in an external cohort.

Results

For each 1 mmol/L decrease in high-density lipoprotein cholesterol (HDL-C), EM risk increased by 55%. Converse

SUBMITTER: Duan Y 

PROVIDER: S-EPMC12628710 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature