Long-term culturing of <i>Pseudomonas aeruginosa</i> in static, minimal nutrient medium results in increased pyocyanin production, reduced biofilm production, and loss of motility.

ABSTRACT: Pseudomonas aeruginosa is a multidrug-resistant opportunistic human pathogen that can survive in many natural and anthropogenic environments. It is a leading cause of morbidity in individuals with cystic fibrosis and is one of the most prevalent pathogens associated with nosocomial infections in the United States. It has been shown that this organism can survive and persist in low-nutrient environments, such as sink drains. How adaptation to these types of environments influences the phenotypic traits of this organism has not been well studied. Here, we implemented an experimental evolution system in which six strains of P. aeruginosa were subjected to low-nutrient conditions over the course of 12 weeks and assessed phenotypic and genotypic changes that occurred as a result o

SUBMITTER: Cecil RE 

PROVIDER: S-EPMC12628827 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature