The outer membrane autotransporters Fap2 and CmpA facilitate specific coaggregation between <i>Fusobacterium nucleatum</i> and <i>Aggregatibacter actinomycetemcomitans</i> serotypes b and d.

ABSTRACT: Periodontal disease is a polymicrobial infection in which Fusobacterium nucleatum and Aggregatibacter actinomycetemcomitans have been identified as key pathogens associated with disease progression. F. nucleatum is capable of coaggregating with several oral bacterial species, including A. actinomycetemcomitans, and these coaggregations play crucial roles in dental plaque formation. In this study, we investigated the coaggregation properties of both bacteria and identified the molecules that mediate their interaction. Among A. actinomycetemcomitans serotypes a, b, c, d, and g, F. nucleatum strains coaggregated specifically with serotypes b and d. The coaggregation between F. nucleatum and A. actinomycetemcomitans serotype b was signifi

SUBMITTER: Tanaka Y 

PROVIDER: S-EPMC12628838 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature