Early initiation of guideline-directed medical therapy in patients with cardiogenic shock supported with Impella^®: a two-center retrospective study.

ABSTRACT:

Background

Determining the optimal timing for initiating guideline-directed medical therapy (GDMT) in survivors of cardiogenic shock remains a clinical challenge. Clinicians must balance the urgency of early intervention to prevent adverse remodeling with the risk of hemodynamic instability. This study tested the hypothesis that initiating GDMT early during the intensive care unit (ICU) stay is associated with improved 6-month clinical outcomes in this high-risk population.

Methods

In a retrospective, two-center study of 42 survivors of Impella^®-supported cardiogenic shock, patients were stratified by their simple GDMT score at ICU discharge (high-score group: score ≥ 4, n = 24 vs. low-score group: score < 4, n = 18). The primary endpoint was a 6-month composite o

SUBMITTER: Yokawa J 

PROVIDER: S-EPMC12628905 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature