A novel biomarker of human exposure to Aedes albopictus based on the Ag5-3 salivary protein from the tiger mosquito.

ABSTRACT:

Background

Mosquito-borne arboviral diseases represent a growing threat and serious worldwide concern for public health authorities. Host immunoglobulin G (IgG) responses to mosquito salivary antigens emerged as a useful additional tool to evaluate human-vector contact, which is crucial for transmission risk assessment and planning vector control interventions. We previously reported that IgG responses to the Aedes albopictus 34k2 salivary protein (al34k2) are suitable, although with some limitations, to reveal variation of human exposure to the tiger mosquito. In this study we evaluated the Ae. albopictus Ag5-3 (alAg5-3), an Antigen 5 family member specifically and abundantly expressed in the saliva of adult females.

Methods

IgG responses to recombinant alAg5-3, as well as

SUBMITTER: Dipaola MG 

PROVIDER: S-EPMC12628915 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature