Dietary patterns, polygenic risk, and kidney cancer incidence: a UK Biobank cohort study.

ABSTRACT:

Background

Diet and genetic risk are established risk factors for kidney cancer, but their interaction remains unclear. This study aims to systematically investigate the associations between various dietary patterns and kidney cancer risk, as well as to evaluate the combined effects of diet and genetic risk on kidney cancer risk.

Methods

We conducted a prospective cohort study involving 113,594 participants from the UK Biobank who completed at least two 24-hour dietary recalls, and adherence to four dietary patterns (Alternate Mediterranean Index (aMED), Alternative Healthy Eating Index 2010 (AHEI), dietary approaches to stop hypertension (DASH), and dietary inflammatory index (DII)) was assessed. Incident kidney cancer cases were ascertained via records. Genetic risk was qu

SUBMITTER: Zou M 

PROVIDER: S-EPMC12628948 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature