Molecular epidemiology, antimicrobial resistance, and virulence determinants of Enterococcus faecium bloodstream isolates: a 7-year study in Shandong, China.

ABSTRACT:

Background

Enterococcus faecium is a major cause of hospital-acquired infections, particularly bloodstream infections, which are associated with high mortality rates. This study aimed to characterize the molecular epidemiology, antimicrobial resistance profiles, and virulence determinants of E. faecium isolates from bloodstream infections in a tertiary hospital in Shandong, China, over a seven-year period (2017-2023).

Results

Among 91 E. faecium isolates, 4 were vancomycin-resistant (VREfm), and 87 were vancomycin-susceptible (VSEfm). High resistance rates (> 87.9%) were observed for ciprofloxacin, levofloxacin, penicillin, ampicillin, and erythromycin. Multilocus sequence typing (MLST) identified 16 sequence types (STs), dominated by ST78 (41.8%) and ST555 (22.0%), with a n

SUBMITTER: Sun H 

PROVIDER: S-EPMC12628980 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature