Trigeminal root demyelination is sufficient to induce trigeminal neuralgia-like facial pain in adult rodents.

ABSTRACT:

Background

Current etiology-centered management guidelines have not brought about satisfactory outcomes for trigeminal neuralgia patients. Therefore, there is an urgent call for pathology-targeted diagnosis and treatment modalities for this intractable disease. Trigeminal root demyelination has been frequently shown or suggested in trigeminal neuralgia patients of diverse etiologies and then naturally regarded as the common pathological cause of this disease. However, this causal relationship has never been validated so far with success in either preclinical or clinical studies. One of the key obstacles is that trigeminal root demyelination per se has not been proven as yet to be sufficient to induce trigeminal neuralgia-like facial pain in animals.

Methods

Trigeminal root d

SUBMITTER: Wang ZY 

PROVIDER: S-EPMC12628996 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature