Comprehensive analysis of the BID gene to uncover the role of novel alternative splicing isoforms in colon adenocarcinoma: a systematic review of literature and bioinformatics analysis.

ABSTRACT:

Background

Colon Adenocarcinoma (COAD) is the second leading cause of cancer-related death worldwide, with a rising incidence. Apoptosis is a key contributor to cancer, serving as a prognostic and diagnostic marker. BID, as a link between extrinsic and intrinsic apoptosis pathways, may play an important role in COAD development.

Materials and methods

A systematic review was conducted to assess the role of the BID gene in COAD. A systematic review was conducted using PubMed, Web of Science, and Scopus up to December 14, 2023. Two reviewers screened articles according to the PRISMA 2020 guidelines, and the risk of bias was assessed using the ROBINS-I tool. The study protocol was registered in PROSPERO (CRD42023455350). A pan-cancer analysis of BID was performed using TCGA and

SUBMITTER: Zangooie A 

PROVIDER: S-EPMC12628997 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature