Construction and validation of a prognostic model for colorectal cancer based on bioinformatics and basement membrane-related genes.

ABSTRACT:

Objectives

Basement membrane-related genes (BMRGs) play a crucial function in the progression of various malignancies. This study aimed to explore the relationship between BMRGs and colon cancer.

Methods

Data from Colorectal Cancer (CRC) were extracted from the Xena and GEO databases, with 224 BMRGs identified from CRC sequencing data. A single-cell data set (GSE132465) was analyzed to compute BM scores, followed by correlation analysis. Differentially expressed genes (DEGs) were derived from the TCGA-COAD colon cancer data set. Prognosis-associated characteristic genes were identified using univariate Cox, Lasso-Cox, and random survival forest (RSF) methods. These genes were incorporated into a multivariate Cox regression model to calculate risk scores. A clinical predictiv

SUBMITTER: Wei J 

PROVIDER: S-EPMC12629019 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature