Global, regional, and national burden of early-onset and late-onset colorectal cancer attributable to high body-mass index from 1990 to 2021: a trend analysis and forecasts up to 2040 based on the global burden of disease study 2021.

ABSTRACT:

Background

The global burden of colorectal cancer (CRC) has been steadily rising. However, a key knowledge gap persists regarding the HBMI-attributable burden in early-onset (EOCRC) versus late-onset (LOCRC) cases. The temporal patterns, geographic heterogeneity, and comparative trends remain poorly characterized, as prior studies often lack stratification by age of onset and detailed analysis across socio-demographic strata.

Objective

This investigation seeks to systematically quantify the burden of EOCRC and LOCRC attributable to HBMI at global, regional, and national levels from 1990 to 2021 and provides projections of the burden through 2040.

Methods

Epidemiological data, including number and rate for EOCRC and LOCRC were obtained from the Global Burden of Disease

SUBMITTER: Yue B 

PROVIDER: S-EPMC12629028 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature