Metabolic, perfusion, and diffusion imaging enhance diagnosis and prognosis of H3K27-altered diffuse midline gliomas.

ABSTRACT:

Background

This study aimed to assess the contributions of metabolism, perfusion, and diffusion kurtosis imaging (DKI) to the diagnosis and prognostic prediction of H3K27-altered diffuse midline gliomas (DMGs).

Methods

Between June 2020 and May 2023, 95 patients (mean age 16.98 years; 61.1% female) with brainstem tumors, including 71 H3K27-altered DMGs and 24 H3K27 wild-type brainstem tumors (referred to as non-DMGs), underwent preoperative conventional and advanced MRI (amide proton transfer-weighted [APTw], arterial spin labeling [ASL], and DKI). Logistic and Cox regressions with leave-one-out cross-validation (LOOCV) were used to evaluate the separate and integrated contributions of advanced MRI to diagnostic and prognostic tasks.

Results

Advanced MRI techniques si

SUBMITTER: Qiu J 

PROVIDER: S-EPMC12629030 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature