Imaging brain inflammation and blood brain barrier permeability in neurological and psychiatric diseases: a review.

ABSTRACT: Neuroinflammation involving glial cell activation and BBB dysfunction has increasingly been recognized as a key feature of neuropsychiatric disorders. In vivo imaging methods, particularly translocator protein positron emission tomography (TSPO-PET) and dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI), have advanced our understanding of glial activation and BBB permeability in conditions such as Alzheimer's disease, Parkinson's disease, epilepsy, multiple sclerosis, Huntington's disease, schizophrenia, and depression. We present key findings from the clinical application of these imaging modalities and highlight critical methodological challenges-including variability in study protocols, tracer selection, input function derivation, and parameter estimation-that currently limi

SUBMITTER: Kovbasyuk Z 

PROVIDER: S-EPMC12629060 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature