Changes in white matter volume and cortical thickness predict internalizing symptoms during early adolescence.

ABSTRACT: We sought to examine whether global structural changes in grey and white matter predict adolescent internalizing symptoms using a 3-year longitudinal design. Using secondary data analysis from the Adolescent Brain Cognitive Development Study, 6,564 participants (53% male, 55% White) were included in analyses. We used linear mixed-effects models to predict adolescent internalizing symptoms (measured at ages 12/13 via caregiver report and self-report) from structural brain metrics. Percent change scores were calculated for whole brain, left, and right hemisphere cortical thickness and global white matter volume (WMV; measured at ages 9/10 and 11/12). Cortical thinning in the left hemisphere, but not the right hemisphere, between ages 9/10 and 11/12 predicted internalizing symptoms at ages 12

SUBMITTER: Cohen ZP 

PROVIDER: S-EPMC12629096 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature