Serum Biomarkers Linked to Disease Activity, Severity, and Methylprednisolone Response in Graves' Orbitopathy: A Proteomic Study.

ABSTRACT:

Purpose

To identify biomarkers related to disease activity, severity and response to intravenous methylprednisolone (IVMP) in Graves' orbitopathy (GO), and to evaluate differences in serum proteome between GO, IgG4-related orbital disease (IgG4-ROD) and idiopathic orbital inflammation (IOI).

Methods

Serum proteomics targeting 368 inflammatory proteins (Olink Explore Inflammation panel) was performed on biobank samples from patients with GO (n = 111), IOI (n = 16), IgG4-ROD (n = 10), and healthy controls (n = 25). GO activity, severity and response to IVMP were assessed retrospectively. Differentially expressed proteins (DEPs) were defined as Log2-fold change <-0.5 or >0.5 and false discovery rate (FDR)-adjusted P < 0.05.

Results

No DEPs were associated with GO activit

SUBMITTER: Hotte GJ 

PROVIDER: S-EPMC12629127 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature