Synthesis, Characterization, Biological Evaluation, DFT Calculations, and Molecular Docking Study of Transition Metal Complexes Derived From a Schiff Base Ligand.

ABSTRACT: The escalating global challenge of antibiotic resistance amid rising oxidative stress emphasizes the critical necessity for innovative antimicrobial strategies. This study, reported synthesis of Schiff base ligand, (Z)-2-[(4-nitrobenzylidene)amino]phenol (HL), derived from condensation between 2-aminophenol and 4-nitrobenzaldehyde, and it Co(II), Ni(II), Cu(II), and Zn(II) complexes. The compounds were characterized using NMR, FTIR, UV-Vis, MS, TGA, SEM-EDX, and elemental (CHN) analysis. In addition, solid-state structure of HL was obtained using single-crystal x-ray diffraction. The characterizations show that the ligand coordinated to the metal ions through the oxygen and nitrogen atoms of phenolic and imine moieties, resulting in a homoleptic mononuclear complexes of the form ML_2</

SUBMITTER: Waziri I 

PROVIDER: S-EPMC12629167 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature