Exploring Bioactive Metabolites From Fusarium falciforme and Aspergillus terreus Isolated From Protease-Rich Fruits: Antifungal, Antitrypanosomal, and Enzymatic Inhibitory Activities.

ABSTRACT: Fungal secondary metabolites display remarkable chemical diversity and biological potential, with applications in agriculture and pharmaceuticals. This study isolated and characterized bioactive metabolites from two phytopathogenic fungi, Fusarium falciforme (from papaya) and Aspergillus terreus (from pineapple), assessing their antifungal and cysteine protease-inhibitory activities. The compounds hymeglusin, fusaridioic acid A, and butyrolactone I exhibited significant antifungal effects, with hymeglusin (IC₅₀ 22.12 µg/mL) inhibiting A. terreus and butyrolactone I (IC₅₀ 39.72 µg/mL) inhibiting F. falciforme. These metabolites also strongly inhibited papain, with IC₅₀ values of 6.24 µM (butyrolactone I), 9.38 µM (hymeglusin), and 28.58 µM (fusaridioic acid

SUBMITTER: de Oliveira Almeida G 

PROVIDER: S-EPMC12629174 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature