Sleep-related changes in astrocytic biomarkers are modulated by <i>APOE</i> ε4 genotype in cognitively unimpaired adults.

ABSTRACT: Astrocytes are key regulators of sleep and neuroinflammatory responses. However, the relationship between objective sleep parameters and astrocytic fluid biomarkers in cognitively unimpaired individuals remains unclear. We examined how sleep architecture relates to astrocytic, neuroaxonal and Alzheimer's disease-related fluid biomarkers in cognitively unimpaired adults and whether age, sex and APOE ε4 moderate these associations. This cross-sectional study included 51 cognitively unimpaired participants from the Sant Pau Initiative on Neurodegeneration cohort. One-night in-lab polysomnography was used to quantify sleep architecture, fragmentation, slow-wave activity and respiratory parameters. CSF biomarkers included glial fibrillary acidic protein (GFAP), chitinase-like-3 protein 1

SUBMITTER: Zhu N 

PROVIDER: S-EPMC12629230 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature