Late-Stage Oxidation of C(sp³)─H Bonds with High Efficiency and Alkyl Group Dihydroxylation of Complex Molecules.

ABSTRACT: The late-stage oxidation of C(sp³)─H bonds is highly valuable for modulating the solubility and binding of bioactive compounds and for diversification of complex molecules. Undirected methods for C(sp³)─H oxidation are valuable for the installation of hydroxyl groups at sites remote from other functional groups present in the molecule, but existing catalysts are limited by low turnover numbers and lengthy ligand syntheses. Perfluorinated ruthenium porphyrins are highly active catalysts for the oxidation of alkyl C─H bonds, but the scope of the transformation with complex molecules under conditions of limiting substrate has not been investigated. We report that carbonylruthenium(II) tetrakis(pentafluorophenyl)porphyrin [Ru(TPFPP)(CO)] catalyzes the selective oxidation

SUBMITTER: Kang YC 

PROVIDER: S-EPMC12629245 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature