Reproductive decision-making and pregnancy in germline <i>CDH1</i> variant carriers.

ABSTRACT:

Background

Diagnosis of a hereditary cancer syndrome may impact family planning, particularly in reproductive age individuals. Factors influencing reproductive decision-making are understudied in individuals with germline CDH1 pathogenic or likely pathogenic (P/LP) variants.

Methods

We characterised reproductive decision-making and perinatal outcomes in 121 individuals aged 18-49 with hereditary diffuse gastric and lobular breast cancer syndrome due to a germline CDH1 P/LP variant.

Results

Half of individuals (50%, 60/121) reported their CDH1 diagnosis impacted family planning. Psychosocial and economic barriers to reproduction were encountered by 47% (56/119) of patients. Additionally, 12% (15/121) of individuals delayed pregnancy to prioritise p

SUBMITTER: Gallanis AF 

PROVIDER: S-EPMC12629316 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature