Cytochrome bd-II oxidase CyxA promotes the pathogenicity of <i>Klebsiella pneumoniae</i> by resisting oxidative stress.

ABSTRACT: Adaptation to oxidative stress is crucial for survival of Klebsiella pneumoniae in external environments and within infected hosts. Cytochrome bd oxidase contributes to oxidative stress resistance and enhances the pathogenicity of several pathogens. In this study, we explored the role of cytochrome bd-II oxidase CyxA in K. pneumoniae's response to oxidative stress and its overall pathogenicity. The expression level of cyxA was significantly increased in response to oxidative stress in the wild-type strain (WT). Deletion of cyxA reduced K. pneumoniae's resistance to exogenous hydrogen peroxide (H₂O₂) and nitric oxide (NO). Additionally, the expression levels of cyxA at 37°C and 41°C were significantly higher compared to 30°C, a

SUBMITTER: Xiao X 

PROVIDER: S-EPMC12629338 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature