IgG binding characteristics of ferret Fcγ receptors.

ABSTRACT: Studies in animal models are essential to expanding the scope of interventions evaluated for safety, immunogenicity, and efficacy in clinical trials. Ferrets (Mustela putorius furo) are a key small-animal model for examining acquisition, replication, transmission, and disease manifestation, with particular relevance in modeling diverse viruses that target the respiratory tract. However, despite use in studies of vaccine immunogenicity and protection, as well as passive antibody transfer, there is little data characterizing antibody and Fc receptor biology in this species. To address this gap, ferret Fcγ receptors (FcγRI, FcγRII, FcγRIII) were identified and recombinantly expressed and characterized for binding to recombinant ferret and human IgG. In general, ferret IgG bound each re

SUBMITTER: Ge X 

PROVIDER: S-EPMC12629343 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature