TSLPR deficiency attenuates AHR independently of eosinophilia and mucus secretion in a chronic HDM mouse model of allergic asthma.

ABSTRACT:

Background

Asthma is marked by chronic airway inflammation, immune dysregulation, and airway remodeling. While TSLP is known to influence allergic diseases like asthma, the role of TSLPR in airway remodeling is not well-defined.

Methods

Using TSLPR-deficient (TSLPR-/-) mice in a chronic HDM asthma model, we assessed lung function, inflammatory cell infiltration, cytokine levels, and antibody production in serum and lung tissues. Airway remodeling was evaluated by examining mucus production, goblet cell metaplasia, and collagen deposition.

Results

TSLPR-/- mice showed lower airway resistance, tissue resistance, and tissue elastance compared to wild-type mice after chronic HDM exposure. TSLPR-/- mice also had reduced HDM-specific IgE levels and decreased IL-4, IL-13, an

SUBMITTER: Koussih L 

PROVIDER: S-EPMC12629416 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature