The interaction of RNA G-quadruplexes from the influenza A virus vRNA with TMPyP4 and BRACO-19 ligands.

ABSTRACT: The influenza virus is an interesting research subject due to its serious threat to global public health. To date, various structural motifs from the influenza A virus (IAV) genome have been studied. Recently, RNA G-quadruplexes (G4s), noncanonical structures formed within the G-rich sequences of the IAV genome, have been reported. These motifs are suggested to be promising antiviral targets, and studying the G4 binding ligands has attracted increasing research interest. We hypothesized that RNA G4s can play a crucial role in IAV replication. This study focused on the interactions between RNA G4s and ligands, which have not been extensively studied in the influenza A virus California/4/2009 (H1N1) to date. Herein, commonly used G4-specific ligands, TMPyP4 and BRACO-19, were selected. First

SUBMITTER: Nalewaj M 

PROVIDER: S-EPMC12629423 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature