The planarian dorsal-ventral boundary regulates anterior-posterior axis growth and patterning.

ABSTRACT: Regeneration can involve the coordination of pattern formation in an outgrowth with the spatial pattern of pre-existing tissues, such as along body axes. Planarian adult axis patterning serves as a robust context for uncovering the mechanisms of such pattern integration. We investigated how the dorsal-ventral boundary (DVB), which surrounds the animal periphery at the dorsal-ventral (DV) median plane, regulates anterior-posterior (AP) axis growth and patterning. We define a spatial DVB gene expression atlas that includes genes encoding signaling, adhesion, and transcription factors. Wnt inhibition results in anterior positional information induction and ectopic head formation that is restricted to the DVB. DVB can be transplanted, and DVB identity can be experimentally induced at ectopic l

SUBMITTER: Maybrun CL 

PROVIDER: S-EPMC12629446 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature