Birth weight discordance, gene expression, and DNA methylation: A scoping review of epigenetic twin studies.

ABSTRACT:

Background

Birth weight is considered as an important indicator of environmental conditions during prenatal development. Molecular mechanisms, including epigenetic modifications, play central roles in the body's adaptation to ever-changing environmental conditions. Twin study designs offer a powerful approach for distinguishing environmental from genetic effects. Specifically, within-pair comparisons of monozygotic twins can be used to differentiate unique individual environmental factors from shared environmental and genetic contributions. Notably, numerous studies in monozygotic twins have shown associations between prenatal environment and birth weight discordance (BWD), and suggested a potential involvement of gene expression and epigenetic factors mediating the association.

SUBMITTER: Wadji DL 

PROVIDER: S-EPMC12629465 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature