Protective effects of L-arginine on gastric ulcer induced by ethanol in rats: Modulation of oxidative stress.

ABSTRACT: Gastric ulcers occur due to an imbalance between harmful and protective factors. This study aimed to examine the effect of L-arginine on ethanol-induced gastric ulcers in rats. In this study, 30 male Wistar rats were divided into five groups: a control group that received saline, group 1 which was treated with 70% ethanol to induce gastric ulcers, group 2 that received saline along with L-arginine at a dose of 500 mg/kg administered intraperitoneally, group 3 that was given ethanol along with L-arginine at the same dose but administered orally, and group 4 which received ethanol together with omeprazole at a dose of 10 mg/kg administered intraperitoneally. After the ethanol treatment induced ulceration, gastric lesions were evaluated, and assays were performed to measure antioxidant enzyme

SUBMITTER: Rahimi K 

PROVIDER: S-EPMC12629469 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature