Different antigenic distance metrics generate similar predictions of influenza vaccine response breadth despite moderate correlation.

ABSTRACT:

Introduction

Influenza continuously evolves to escape population immunity, which makes formulating a vaccine challenging. Antigenic differences between vaccine strains and circulating strains can affect vaccine effectiveness (VE). Quantifying the antigenic difference between vaccine strains and circulating strains can aid interpretation of VE, and several antigenic distance metrics have been discussed in the literature. Here, we compare how the predicted breadth of vaccine-induced antibody response varies when different metrics are used to calculate antigenic distance.

Methods

We analyzed data from a seasonal influenza vaccine cohort that collected serum samples from 2013/14 - 2017/18 at three study sites. The data include pre- and post-vaccination HAI titers to the vaccine

SUBMITTER: Billings WZ 

PROVIDER: S-EPMC12629490 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature