Usefulness of 3D joint space width on weight-bearing CT in comparison with 2D joint space width on radiographs for predicting 24-month worsening of knee osteoarthritis pain and function in the MOST study.

ABSTRACT:

Objective

This study compared the predictive validity of three-dimensional joint space width (3D-JSW) on weight-bearing computed tomography (WBCT) versus two-dimensional joint space width at predetermined mediolateral locations (2D-JSW_x) on radiographs for worsening knee pain and physical function over 24 months.

Design

Data from 302 participants (425 knees) in the Multicenter Osteoarthritis Study (MOST) were analyzed. Baseline assessments included bilateral standing radiographs for 2D-JSW_x and WBCT for 3D-JSW. Minimal clinically important worsening (MCIW) of pain (Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) pain subscale) and function (20-m walk, sit-to-stand, WOMAC function subscale) over 24 months was assessed. Logistic reg

SUBMITTER: Yoshikawa R 

PROVIDER: S-EPMC12629503 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature