Serotonin 5-HT_2C Receptor Signaling Analysis Reveals Psychedelic Biased Agonism.

ABSTRACT: The serotonin 2C receptor (5-HT_2C) is a G protein-coupled receptor implicated in multiple physiological and psychological processes and has been investigated as a therapeutic target for neuropsychiatric conditions such as obesity, drug abuse, and depression. With renewed interest in serotonergic psychedelics for treating depression, 5-HT_2C may contribute to psychedelic-induced therapeutic effects. Despite earlier evidence of 5-HT_2C G protein coupling promiscuity, the full signaling landscape remains incompletely characterized, which may help explain the limited efficacy and potential cancer risks associated with lorcaserin. Here, we provide a comprehensive analysis of 5-HT_2C signaling, confirming and building upon previous findings that the recep

SUBMITTER: Bonniwell EM 

PROVIDER: S-EPMC12629614 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature