LncRNA NEAT1 Knockdown Alleviates Macrophage Ferroptosis and Atherosclerosis by Suppressing STAT3 Activation.

ABSTRACT:

Background

This study aimed to investigate the role and mechanism of long noncoding RNA nuclear-enriched abundant transcript 1 (NEAT1) in macrophage ferroptosis during atherosclerosis (AS).

Methods

The clinical characteristics and disease severity were assessed in 84 patients with coronary heart disease (CHD). The role of NEAT1 in high-fat diet-induced AS and the impact of exercise were examined in APOE^-/- and NEAT1^-/- mice. Human monocyte THP-1 cells were utilized to explore cellular mechanisms underlying AS. Quantitative real-time PCR, immunofluorescence staining, and Western blot analysis were employed to analyze gene expression. Transmission electron microscopy and fluorescence in situ hybridization were used to examine cellular and tissue-level cha

SUBMITTER: Wang D 

PROVIDER: S-EPMC12629693 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature