Korean red ginseng extract suppresses food allergy by remodeling the gut microbiota and restoring immune homeostasis in IL4ra^F709 mice.

ABSTRACT:

Background

Food allergy (FA) is a growing health concern with limited therapeutic options. While Korean Red Ginseng Extract (KRGE) exhibits immunomodulatory and microbiota-modulating properties, its specific effects and mechanisms in FA are not fully understood.

Methods

We evaluated the anti-allergic efficacy of KRGE in IL4ra^F709 mice, a model genetically predisposed to IgE-mediated anaphylaxis. Mice were sensitized with ovalbumin(OVA) and staphylococcal enterotoxin B (SEB) and challenged with OVA. KRGE was administered orally prior to and during sensitization. Clinical symptoms, serum IgE levels, IL-33 levels, and intestinal histology were assessed. Mesenteric lymph nodes and Peyer's patches immune cell populations were analyzed by flow cytometry. Fecal microbiot

SUBMITTER: Choi S 

PROVIDER: S-EPMC12629723 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature